Revised:  07/02/2008

Memo for June 24, 2008

 

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New Jersey Department of Agriculture

 

Memo

To: Veterinarians

From: Nancy E. Halpern, DVM, New Jersey State Veterinarian

Date: June 24, 2008

Re: COMFORTISR and ivermectin interaction Safety Warning Notification

 

The U.S. Food and Drug Administration (FDA) Center for Veterinary Medicine (CVM) recently announced that it has received reports of adverse reactions in dogs receiving the drug ComfortisR (spinosad) concurrently with high, extra-label doses of the drug ivermectin. The clinical signs of these adverse reactions are consistent with ivermectin toxicity.

 

ComfortisR (spinosad), manufactured by Elanco Animal Health, a division of Eli Lilly and Company, is a monthly oral, chewable tablet used for the prevention and treatment of flea infestations on dogs. Veterinarians who use high, extra-label doses of ivermectin to treat dogs with non-responsive demodectic mange and other conditions should be aware that some dogs have developed signs of ivermectin toxicity when ivermectin is used concurrently with ComfortisR (spinosad).

 

CVM and Elanco Animal Health are advising veterinarians that dogs receiving extra-label doses of ivermectin should not receive concurrent treatment with ComfortisR (spinosad).

 

CVM is working with Elanco Animal Health as they address this issue. Additional information regarding this safety warning can be obtained on the Elanco Animal Health website.

 

 

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